Characterization of a phenotypically unique population of CD13+ dendritic cells resident in the spleen

Clin Vaccine Immunol. 2006 Sep;13(9):1064-9. doi: 10.1128/CVI.00178-06.

Abstract

Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a(+) CD11c(+) CD13(+) CD172(+) CD205(+) population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / metabolism
  • Antigen-Presenting Cells / immunology
  • CD13 Antigens / metabolism*
  • Cattle
  • Cell Culture Techniques
  • Cell Separation
  • Cells, Cultured
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Histocompatibility Antigens Class II / immunology
  • Immunoglobulin Isotypes / analysis
  • Immunoglobulin Isotypes / immunology
  • Male
  • Phenotype*
  • Spleen / cytology*
  • Spleen / immunology*

Substances

  • Antibodies, Monoclonal
  • Histocompatibility Antigens Class II
  • Immunoglobulin Isotypes
  • CD13 Antigens