Abstract
Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a(+) CD11c(+) CD13(+) CD172(+) CD205(+) population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / metabolism
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Antigen-Presenting Cells / immunology
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CD13 Antigens / metabolism*
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Cattle
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Cell Culture Techniques
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Cell Separation
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Cells, Cultured
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Dendritic Cells / cytology
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Dendritic Cells / immunology*
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Dendritic Cells / metabolism
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Histocompatibility Antigens Class II / immunology
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Immunoglobulin Isotypes / analysis
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Immunoglobulin Isotypes / immunology
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Male
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Phenotype*
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Spleen / cytology*
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Spleen / immunology*
Substances
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Antibodies, Monoclonal
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Histocompatibility Antigens Class II
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Immunoglobulin Isotypes
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CD13 Antigens