Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT

V Sol; V Chaleix; Y Champavier; R Granet; Y-M Huang; P Krausz

doi:10.1016/j.bmc.2006.08.004

Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT

Bioorg Med Chem. 2006 Dec 1;14(23):7745-60. doi: 10.1016/j.bmc.2006.08.004. Epub 2006 Sep 7.

Authors

V Sol¹, V Chaleix, Y Champavier, R Granet, Y-M Huang, P Krausz

Affiliation

¹ Université de Limoges - Laboratoire de Chimie des Substances Naturelles 123, Avenue Albert Thomas-87060 Limoges, France. vincent.sol@unilim.fr

PMID: 16959490
DOI: 10.1016/j.bmc.2006.08.004

Abstract

Syntheses of new glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain are described. A detailed 1H and 13C NMR study allows their complete structural elucidation. The UV-visible, fluorescence and MALDI mass spectra are also presented. Photocytotoxicities of these compounds against K562 leukaemia cell line are compared to those of Photofrin II.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Survival / drug effects
Dihematoporphyrin Ether
Dimerization
Glycosylation
Humans
K562 Cells
Magnetic Resonance Spectroscopy
Molecular Structure
Photochemotherapy / methods*
Porphyrins / chemical synthesis*
Porphyrins / pharmacology*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrum Analysis
Structure-Activity Relationship

Substances

Porphyrins
Dihematoporphyrin Ether