Stereoselective functionalization of the 1'-position of 4'-thionucleosides

Prashantha Gunaga; Hea Ok Kim; Hyuk Woo Lee; Dilip K Tosh; Jae-Sang Ryu; Sun Choi; Lak Shin Jeong

doi:10.1021/ol061548z

Stereoselective functionalization of the 1'-position of 4'-thionucleosides

Org Lett. 2006 Sep 14;8(19):4267-70. doi: 10.1021/ol061548z.

Authors

Prashantha Gunaga¹, Hea Ok Kim, Hyuk Woo Lee, Dilip K Tosh, Jae-Sang Ryu, Sun Choi, Lak Shin Jeong

Affiliation

¹ Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.

PMID: 16956203
DOI: 10.1021/ol061548z

Abstract

Stereoselective synthesis of novel 1'-alpha-substituted-4'-thionucleosides was achieved starting from D-gulonic acid gamma-lactone via stereoselective nucleophilic substitution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Oxidation-Reduction
Stereoisomerism
Sugar Acids / chemistry
Thionucleosides / chemistry*

Substances

Sugar Acids
Thionucleosides
gulonolactone