Rapid GC-MS analysis of methamphetamine and its metabolites in urine--application of a short narrow-bore capillary column to GC-MS

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Oct 2;842(2):116-20. doi: 10.1016/j.jchromb.2006.08.018. Epub 2006 Sep 1.

Abstract

A rapid analysis of methamphetamine and its metabolites in urine was performed by gas chromatography-mass spectrometry (GC-MS) using a short narrow-bore capillary column (NBC) (5 m x 0.1 mm I.D.). For detection, selected ion monitoring (SIM) was performed for the characteristic ions of each of the compounds. The analytes were independently detected within 2 min. Linearity was demonstrated over a range from 25-2500 ng/ml. As an application of this study, a urine sample from a drug-abuse suspect was analyzed. The analytes from the actual sample were detected with reasonable reproducibility. The results indicate the possibility of rapid analysis using a conventional GC-MS with a short NBC at a relatively low inlet pressure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Gas Chromatography-Mass Spectrometry / instrumentation
  • Gas Chromatography-Mass Spectrometry / methods*
  • Humans
  • Male
  • Methamphetamine / metabolism
  • Methamphetamine / urine*
  • Reproducibility of Results

Substances

  • Methamphetamine