CTX-M-37 in Salmonella enterica serotype Isangi from Durban, South Africa

U Govinden; C Mocktar; P Moodley; A W Sturm; S Y Essack

doi:10.1016/j.ijantimicag.2006.05.028

CTX-M-37 in Salmonella enterica serotype Isangi from Durban, South Africa

Int J Antimicrob Agents. 2006 Oct;28(4):288-91. doi: 10.1016/j.ijantimicag.2006.05.028. Epub 2006 Sep 1.

Authors

U Govinden¹, C Mocktar, P Moodley, A W Sturm, S Y Essack

Affiliation

¹ School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4000, South Africa. Govindenu@ukzn.ac.za

PMID: 16949257
DOI: 10.1016/j.ijantimicag.2006.05.028

Abstract

Beta-lactamase-mediated resistance was investigated in 59 putative extended-spectrum beta-lactamase (ESBL)-positive Salmonella spp. from the paediatric ward of a tertiary hospital in Durban, South Africa. Three Salmonella enterica serotype Isangi cultured from stool samples were multidrug resistant, with susceptibility only to meropenem, piperacillin/tazobactam and cefoxitin. Isoelectric focusing revealed beta-lactamases with isoelectric points of pI 5.8, 6.8 and 7.2. Sequencing identified beta-lactamases CTX-M-37 and TEM-1. To our knowledge, this is the first report of CTX-M-37 from S. enterica serotype Isangi in South Africa.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
DNA, Bacterial / genetics
DNA, Bacterial / isolation & purification
Drug Resistance, Multiple*
Humans
Isoelectric Focusing
Microbial Sensitivity Tests
Molecular Sequence Data
Salmonella Infections / epidemiology
Salmonella Infections / microbiology*
Salmonella enterica / drug effects*
Salmonella enterica / enzymology
Salmonella enterica / genetics
South Africa / epidemiology
beta-Lactamases / biosynthesis
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
DNA, Bacterial
beta-Lactamases
beta-lactamase CTX-M-37, Salmonella enterica