Extreme thrombocytosis associated with transient myeloproliferative disorder with Down Syndrome with t(11;17)(q13;q21)

Pediatr Blood Cancer. 2008 Mar;50(3):643-4. doi: 10.1002/pbc.21029.

Abstract

A female patient with Down Syndrome (DS) had neonatal thrombocytosis with platelet counts exceeding 2,000 x 10(3)/microL and transient myeloproliferative disorder (TMD). Platelet counts remained elevated the first 2 months of life. A translocation located between chromosomes 17 and 11 was observed. We describe a patient with thrombocytosis and TMD showing an 11q13 translocation. The leukocytosis and thrombocytosis improved after an exchange transfusion.

Publication types

  • Case Reports

MeSH terms

  • Chromosomes, Human, Pair 11 / genetics
  • Chromosomes, Human, Pair 11 / ultrastructure*
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 17 / ultrastructure*
  • Down Syndrome / complications*
  • Down Syndrome / genetics
  • Exchange Transfusion, Whole Blood
  • Female
  • Fetal Distress / complications
  • Fetal Growth Retardation
  • Humans
  • Hypoxia / etiology
  • Hypoxia / therapy
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infant, Small for Gestational Age
  • Leukocytosis / complications
  • Leukocytosis / congenital
  • Leukocytosis / genetics
  • Leukocytosis / therapy
  • Thrombocytosis / complications
  • Thrombocytosis / congenital*
  • Thrombocytosis / genetics
  • Thrombocytosis / therapy
  • Translocation, Genetic*