Cardiac resynchronisation therapy for heart failure

Int J Clin Pract. 2006 Sep;60(9):1107-14. doi: 10.1111/j.1742-1241.2006.01015.x.

Abstract

Cardiac resynchronisation therapy (CRT) reduces symptoms and improves left ventricular function in chronic heart failure (CHF) patients with left ventricular systolic dysfunction and prolonged QRS duration. Recent studies have demonstrated a reduction in mortality associated with CRT. When combined with an implantable cardioverter defibrillator (ICD) reduction in mortality is likely to reduce further. Cardiac resynchronisation therapy is well tolerated and free from compliance issues and therefore should be considered for all suitable patients. Identifying patients who will derive maximum benefit requires further study and has health economic implications. We review here the CRT trial evidence as well as the implantation technique and complications. We also describe a case report where an intra-aortic balloon pump was used successfully as a bridge to CRT to treat a patient with end-stage heart failure.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Atrial Fibrillation / therapy
  • Cardiac Pacing, Artificial / economics
  • Cardiac Pacing, Artificial / methods*
  • Cardiac Pacing, Artificial / mortality
  • Clinical Trials as Topic
  • Heart Block / therapy
  • Heart Failure / economics
  • Heart Failure / mortality
  • Heart Failure / therapy*
  • Heart-Assist Devices
  • Humans
  • Male
  • Pacemaker, Artificial / economics
  • Prosthesis Implantation