A myelin basic protein antibody cascade in purified IgG from cerebrospinal fluid of multiple sclerosis patients

K G Warren; I Catz

doi:10.1016/0022-510x(90)90053-p

A myelin basic protein antibody cascade in purified IgG from cerebrospinal fluid of multiple sclerosis patients

J Neurol Sci. 1990 Apr;96(1):19-27. doi: 10.1016/0022-510x(90)90053-p.

Authors

K G Warren¹, I Catz

Affiliation

¹ Department of Medicine (Neurology), University of Alberta, Edmonton, Canada.

PMID: 1693669
DOI: 10.1016/0022-510x(90)90053-p

Abstract

Immunoglobulin G (IgG) was purified by affinity chromatography from the CSF of multiple sclerosis (MS) patients and controls. In MS patients, the IgG fraction contains anti-myelin basic protein (anti-MBP), anti-MBP neutralizing antibody and an antibody which inhibits neutralization of anti-MBP. Anti-MBP was detected in patients with acute relapses, anti-MBP neutralizing antibody was present in patients in clinical remission and the inhibiting antibody was detected in patients with chronically progressing MS. A myelin basic protein antibody cascade could be involved in the mechanism of MS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / cerebrospinal fluid*
Humans
Multiple Sclerosis / cerebrospinal fluid
Multiple Sclerosis / immunology*
Myelin Basic Protein / immunology*

Substances

Autoantibodies
Myelin Basic Protein