Abstract
The manipulation of the chemical structure of proteins beyond what is feasible with standard genetics, offers a powerful strategy to investigate protein mechanisms. By allowing the incorporation of biophysical probes, unnatural amino acids, and post-translational modifications in proteins, chemistry-driven approaches have greatly contributed to the understanding of the molecular basis of protein function.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Amino Acids / chemistry
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Animals
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GTP Phosphohydrolases / chemistry
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Histones / chemistry
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Ion Channels
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Molecular Probes
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Protein Engineering / methods
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Protein Processing, Post-Translational
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Protein Tyrosine Phosphatases / chemistry
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Proteins / chemical synthesis*
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Proteins / chemistry*
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Proteins / physiology
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Ribonucleotide Reductases / chemistry
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Structure-Activity Relationship
Substances
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Amino Acids
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Histones
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Ion Channels
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Molecular Probes
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Proteins
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Ribonucleotide Reductases
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Protein Tyrosine Phosphatases
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GTP Phosphohydrolases