Design of highly efficient receptor sites by combination of cyclodextrin units and molecular cavity in TiO2 ultrathin layer

Biosens Bioelectron. 2006 Sep 15;22(3):388-92. doi: 10.1016/j.bios.2006.06.013. Epub 2006 Aug 28.

Abstract

A highly effective approach was developed for sensitive detection of organic substances in water. In order to achieve high sensitivity and selective detection for aromatic compounds, cyclodextrin (CD) hosts and imprinting effects were combined to fabricate binding sites within TiO(2) ultrathin layer. The electrode surface was modified with ultrathin TiO(2) gel film containing a 2:1 complex of beta-CD and bisphenol A (BPA), and then the BPA moiety was removed by washing. The resulting BPA-imprinted TiO(2)/beta-CD film showed specific and sensitive detection of BPA, as confirmed by quartz crystal microbalance (QCM) and cyclic surface-polarization impedance (cSPI) measurements. The high selectivity for BPA relative to structurally related guest molecules was estimated to be 1.6-3.4 at the guest concentration of 2x10(-7)M, and was considered to arise from the synergic effect of the binding site.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzhydryl Compounds
  • Binding Sites
  • Biosensing Techniques / instrumentation*
  • Biosensing Techniques / methods
  • Coated Materials, Biocompatible / chemistry*
  • Cyclodextrins / chemistry*
  • Electrochemistry / instrumentation*
  • Electrochemistry / methods
  • Environmental Monitoring / instrumentation
  • Environmental Monitoring / methods
  • Equipment Design
  • Equipment Failure Analysis
  • Microelectrodes*
  • Phenols / analysis*
  • Surface Properties
  • Titanium / chemistry*
  • Water Pollutants, Chemical / analysis

Substances

  • Benzhydryl Compounds
  • Coated Materials, Biocompatible
  • Cyclodextrins
  • Phenols
  • Water Pollutants, Chemical
  • titanium dioxide
  • Titanium
  • bisphenol A