Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks

Alongkorn Amonsin; Salin Chutinimitkul; Nuananong Pariyothorn; Thaweesak Songserm; Sudarat Damrongwantanapokin; Suphasawatt Puranaveja; Rungroj Jam-On; Namdee Sae-Heng; Sunchai Payungporn; Apiradee Theamboonlers; Arunee Chaisingh; Rachod Tantilertcharoen; Sanipa Suradhat; Roongroje Thanawongnuwech; Yong Poovorawan

doi:10.1016/j.virusres.2006.06.016

Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks

Virus Res. 2006 Dec;122(1-2):194-9. doi: 10.1016/j.virusres.2006.06.016. Epub 2006 Aug 28.

Authors

Alongkorn Amonsin¹, Salin Chutinimitkul, Nuananong Pariyothorn, Thaweesak Songserm, Sudarat Damrongwantanapokin, Suphasawatt Puranaveja, Rungroj Jam-On, Namdee Sae-Heng, Sunchai Payungporn, Apiradee Theamboonlers, Arunee Chaisingh, Rachod Tantilertcharoen, Sanipa Suradhat, Roongroje Thanawongnuwech, Yong Poovorawan

Affiliation

¹ Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.

PMID: 16935377
DOI: 10.1016/j.virusres.2006.06.016

Abstract

Three major outbreaks of avian influenza (AI) occurred in Thailand. During the third episode in October 2005, we have isolated H5N1 viruses from one human case and three poultry cases. The whole genomes of AI viruses from human, chickens and quail from the outbreaks were characterized. Sequence analysis of eight gene segments revealed that the 2005 H5N1 viruses isolated in October 2005 were closely related to those recovered from chicken, tiger(s) and human(s) in January and July 2004. In addition, the genetic changes of the AI isolates at the HA cleavage site have been observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Outbreaks* / veterinary
Genome, Viral*
Hemagglutinin Glycoproteins, Influenza Virus / genetics
Humans
Influenza A Virus, H5N1 Subtype / genetics*
Influenza A Virus, H5N1 Subtype / isolation & purification*
Influenza in Birds / epidemiology
Influenza in Birds / virology*
Influenza, Human / virology*
Molecular Sequence Data
Mutation
Phylogeny
Poultry / virology
Quail / virology
Sequence Homology
Thailand / epidemiology
Tigers / virology

Substances

Hemagglutinin Glycoproteins, Influenza Virus
hemagglutinin, avian influenza A virus

Associated data

GENBANK/DQ334757
GENBANK/DQ334758
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GENBANK/DQ334760
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