Vanadium complex of 2-(2'-Pyridyl)-4,5-dicyanoimidazole showing spermicidal and cytotoxic properties

Gregory B Less; Nathan W Ockwig; Paul G Rasmussen; Gary D Smith; Laura M Keller; John C Drach

doi:10.1021/ic060545f

Vanadium complex of 2-(2'-Pyridyl)-4,5-dicyanoimidazole showing spermicidal and cytotoxic properties

Inorg Chem. 2006 Sep 4;45(18):7105-10. doi: 10.1021/ic060545f.

Authors

Gregory B Less¹, Nathan W Ockwig, Paul G Rasmussen, Gary D Smith, Laura M Keller, John C Drach

Affiliation

¹ Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA. gless@umich.edu

PMID: 16933910
DOI: 10.1021/ic060545f

Abstract

Two complexes having the formulas VO(DCIPy)2(H2O).1.5H2O and VO(DCIPy)2(H2O).2MeOH have been synthesized and characterized (DCIPy = 2-(2'-pyridyl)-4,5-dicyanoimidazolato). The methanol solvated species has been studied by X-ray diffraction, and single crystals form in the space group P2(1)/n. The hydrated species was studied by electron paramagnetic resonance spectroscopy in both the solid state and in a frozen solution, and the values of A( parallel) examined using the additivity relationship. The hydrated species was shown to exhibit both spermicidal and cytoxic properties.

MeSH terms

Antiviral Agents / chemistry
Antiviral Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Crystallography, X-Ray
Fibroblasts / drug effects
Humans
Imidazoles / chemistry*
Male
Microbial Sensitivity Tests
Models, Molecular
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Sperm Motility / drug effects
Spermatocidal Agents / chemistry
Spermatocidal Agents / pharmacology*
Spermatozoa / drug effects
Structure-Activity Relationship
Time Factors
Vanadium / chemistry*

Substances

2-(2'-pyridyl)-4,5-dicyanoimidazole
Antiviral Agents
Imidazoles
Organometallic Compounds
Spermatocidal Agents
Vanadium