Discovering new MAP kinase inhibitors

Paul Shapiro

doi:10.1016/j.chembiol.2006.08.001

Discovering new MAP kinase inhibitors

Chem Biol. 2006 Aug;13(8):807-9. doi: 10.1016/j.chembiol.2006.08.001.

Author

Paul Shapiro¹

Affiliation

¹ Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Room 536, 20 North Pine Street, Baltimore, MD 21201, USA.

PMID: 16931329
DOI: 10.1016/j.chembiol.2006.08.001

Abstract

The current study by Kim et al. (in this issue of Chemistry & Biology) uses a genetic approach with the yeast Schizosaccharomyces pombe to identify a highly specific inhibitor of Spc1 MAP kinase that competes with protein substrates for Spc1 interactions, but not with ATP binding.

Publication types

Review
Comment

MeSH terms

Binding Sites
Mitogen-Activated Protein Kinases / antagonists & inhibitors*
Mitogen-Activated Protein Kinases / genetics
Protein Kinase Inhibitors / chemical synthesis*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Schizosaccharomyces / enzymology
Structure-Activity Relationship

Substances

Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases