Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr

Nisakorn Saewan; John D Sutherland; Kan Chantrapromma

doi:10.1016/j.phytochem.2006.07.005

Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr

Phytochemistry. 2006 Oct;67(20):2288-93. doi: 10.1016/j.phytochem.2006.07.005. Epub 2006 Aug 23.

Authors

Nisakorn Saewan¹, John D Sutherland, Kan Chantrapromma

Affiliation

¹ School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand. nisakorn@mfu.ac.th

PMID: 16930641
DOI: 10.1016/j.phytochem.2006.07.005

Abstract

Five tetranortriterpenoids, domesticulide A-E (1-5), were isolated from seeds of Lansium domesticum Corr. together with 11 known triterpenoids (6-16). Their structures were elucidated by analysis of their spectroscopic data. Compounds 2, 3, 4, 7, 8, 10, 11, and 15 showed antimalarial activity against Plasmodium falciparum with IC(50)'s of 2.4-9.7 microg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemistry
Antimalarials / isolation & purification
Antimalarials / pharmacology*
Drug Evaluation, Preclinical
Limonins / chemistry
Limonins / isolation & purification
Limonins / pharmacology*
Meliaceae / chemistry*
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plasmodium falciparum / drug effects*
Seeds / chemistry*

Substances

Antimalarials
Limonins
Plant Extracts