Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus

Org Lett. 2006 Aug 31;8(18):4067-70. doi: 10.1021/ol061556f.

Authors

Katherine N Maloney¹, Wenshan Hao, Jun Xu, Jay Gibbons, John Hucul, Deborah Roll, Sean F Brady, Frank C Schroeder, Jon Clardy

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / metabolism
Antineoplastic Agents / pharmacology
Bridged Bicyclo Compounds, Heterocyclic / chemistry*
Bridged Bicyclo Compounds, Heterocyclic / metabolism
Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
Cell Line, Tumor
Fungi / metabolism*
Heterocyclic Compounds, 2-Ring / chemistry*
Heterocyclic Compounds, 2-Ring / metabolism
Heterocyclic Compounds, 2-Ring / pharmacology*
Humans
Inhibitory Concentration 50
Molecular Structure
STAT3 Transcription Factor / antagonists & inhibitors*
Signal Transduction / drug effects

Substances

Antineoplastic Agents
Bridged Bicyclo Compounds, Heterocyclic
Heterocyclic Compounds, 2-Ring
STAT3 Transcription Factor
phaeosphaeride A

Grants and funding