Synthesis of cryptothilone 1, the first cryptophycin-epothilone hybrid

Org Lett. 2006 Aug 31;8(18):3947-50. doi: 10.1021/ol0614020.

Abstract

A hybrid structure was synthesized in which one portion is characteristic of a cryptophycin and a second sector bears the signature of an epothilone. The hybrid, in contrast to parent cryptophycin and epothilone systems, showed no effect on the tubulin assembly reaction.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Depsipeptides / chemistry*
  • Epothilones / chemical synthesis
  • Epothilones / chemistry*
  • Molecular Structure
  • Peptides, Cyclic / chemistry*

Substances

  • Depsipeptides
  • Epothilones
  • Peptides, Cyclic
  • cryptothilone 1
  • cryptophycin