Abstract
A hybrid structure was synthesized in which one portion is characteristic of a cryptophycin and a second sector bears the signature of an epothilone. The hybrid, in contrast to parent cryptophycin and epothilone systems, showed no effect on the tubulin assembly reaction.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Depsipeptides / chemistry*
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Epothilones / chemical synthesis
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Epothilones / chemistry*
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Molecular Structure
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Peptides, Cyclic / chemistry*
Substances
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Depsipeptides
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Epothilones
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Peptides, Cyclic
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cryptothilone 1
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cryptophycin