Abstract
In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C. albicans infection more rapidly than monotherapy with either drug. Calcineurin, the target of CsA, was also found to contribute to pathogenicity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antifungal Agents / pharmacology
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Antifungal Agents / therapeutic use*
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Calcineurin / physiology*
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Calcineurin Inhibitors*
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Candida albicans / drug effects*
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Candida albicans / physiology
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Candidiasis / drug therapy*
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Candidiasis / microbiology*
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Corneal Diseases / drug therapy*
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Corneal Diseases / microbiology*
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Cyclosporine / therapeutic use
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Fluconazole / pharmacology
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Fluconazole / therapeutic use*
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Immunosuppressive Agents / pharmacology
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Keratitis / drug therapy
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Keratitis / microbiology
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Mice
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Mice, Inbred BALB C
Substances
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Antifungal Agents
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Calcineurin Inhibitors
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Immunosuppressive Agents
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Cyclosporine
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Fluconazole
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Calcineurin