Abstract
A Francisella tularensis live vaccine strain mutant (sodB(Ft)) with reduced Fe-superoxide dismutase gene expression was generated and found to exhibit decreased sodB activity and increased sensitivity to redox cycling compounds compared to wild-type bacteria. The sodB(Ft) mutant also was significantly attenuated for virulence in mice. Thus, this study has identified sodB as an important F. tularensis virulence factor.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Bacterial Proteins / genetics*
-
Bacterial Vaccines / genetics
-
Francisella tularensis / enzymology*
-
Francisella tularensis / pathogenicity
-
Francisella tularensis / physiology
-
Gene Deletion
-
Hydrogen Peroxide / pharmacology
-
Mice
-
Mice, Inbred BALB C
-
Mice, Inbred C57BL
-
Oxidative Stress
-
Paraquat / pharmacology
-
Superoxide Dismutase / genetics*
-
Tularemia / microbiology*
-
Vaccines, Attenuated / genetics
-
Virulence
Substances
-
Bacterial Proteins
-
Bacterial Vaccines
-
Vaccines, Attenuated
-
Hydrogen Peroxide
-
SodB protein, Bacteria
-
Superoxide Dismutase
-
Paraquat