Molecular biology: silencing unlimited

Curr Biol. 2006 Aug 22;16(16):R635-8. doi: 10.1016/j.cub.2006.07.033.

Abstract

Heterochromatin domains are essential for normal chromosome functions. The Eri1 ribonuclease is a negative regulator of the RNA interference machinery; recent studies have shown that, in fission yeast lacking Eri1, heterochromatin formation is more promiscuous.

Publication types

  • Review
  • Comment

MeSH terms

  • Exoribonucleases / metabolism*
  • Gene Expression Regulation, Fungal*
  • Heterochromatin / metabolism
  • Heterochromatin / physiology*
  • Models, Biological*
  • RNA Interference*
  • Schizosaccharomyces

Substances

  • Heterochromatin
  • Eri1 protein, S pombe
  • Exoribonucleases