S-layer proteins as key components of a versatile molecular construction kit for biomedical nanotechnology

Mini Rev Med Chem. 2006 Aug;6(8):909-20. doi: 10.2174/138955706777935026.

Abstract

Surface (S)-layer proteins and S-layer fusion proteins incorporating functional sequences, self-assemble into monomolecular lattices on solid supports and on various lipid structures. Based on these S-layer proteins, supramolecular assemblies can be constructed which are envisaged for label-free detection systems, as affinity matrix, as anti-allergic immuno-therapeutics, as membrane protein-based screening devices, and as drug targeting and delivery systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Anti-Allergic Agents / therapeutic use
  • Bacterial Proteins / chemistry*
  • Biomimetics*
  • Biosensing Techniques / methods*
  • Drug Delivery Systems
  • Drug Design
  • Membrane Glycoproteins / chemistry*
  • Molecular Structure
  • Nanotechnology / methods*

Substances

  • Anti-Allergic Agents
  • Bacterial Proteins
  • Membrane Glycoproteins
  • S-layer proteins