[Evaluation of locomotor activity after a local induction of toxic demyelination in the brainstem of Wistar rats]

Arq Neuropsiquiatr. 2006 Jun;64(2B):496-503. doi: 10.1590/s0004-282x2006000300027.
[Article in Portuguese]

Abstract

Ethidium-bromide (EB)-induced lesions have been used to investigate the incomplete remyelination in the central nervous system, as well as to evaluate therapeutic strategies to accelerate the reconstruction of the lost myelin sheaths. Although many electrophysiologic studies were performed in situations of experimental demyelination and remyelination, their behavioural effects have not been properly analyzed. In this study, we investigated ultrastructurally the EB - demyelinating lesions as well as the locomotor activity of rats during the beam walking test after a focal induction of demyelination using the EB model in the ventral surface of the brainstem. It was observed the occurrence of locomotor deficits until 31 days post-injection, as well as that subsequent remyelination was related to the return of the lost function.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Brain Stem / drug effects*
  • Brain Stem / pathology
  • Brain Stem / physiopathology
  • Demyelinating Diseases / chemically induced
  • Demyelinating Diseases / pathology
  • Demyelinating Diseases / physiopathology*
  • Disease Models, Animal
  • Ethidium
  • Male
  • Motor Activity / physiology*
  • Myelin Sheath / drug effects*
  • Myelin Sheath / pathology
  • Rats
  • Rats, Wistar
  • Time Factors

Substances

  • Ethidium