Structure elucidation of fungal sespendole, an inhibitor of lipid droplet synthesis in macrophages

J Antibiot (Tokyo). 2006 Jun;59(6):338-44. doi: 10.1038/ja.2006.47.

Abstract

A new fungal metabolite named sespendole was isolated as an inhibitor of lipid droplet synthesis in mouse macrophages from the culture broth of the fungal strain Pseudobotrytis terrestris FKA-25. The structure and stereochemistry of sespendole were elucidated by spectroscopic studies including various NMR spectral analyses, exciton chirality experiments and the modified Mosher method. Sespendole was found to possess a new indolosesquiterpene skeleton modified with two isoprenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Indoles / chemistry*
  • Indoles / isolation & purification
  • Lipid Metabolism / drug effects*
  • Macrophages / metabolism*
  • Mice
  • Molecular Conformation

Substances

  • Diterpenes
  • Indoles
  • sespendole