This article reports on the first patient-fitted chromium cobalt removable partial denture framework produced by computer-assisted design, computer-assisted manufacture and rapid prototype technologies. Once the dental cast was scanned, virtual surveying and design of the framework on a 3-dimensional computer model was accomplished. A rapid prototype machine was used for direct fabrication of the alloy framework. Traditional finishing techniques were applied, the framework was assessed by a clinician in a conventional manner, fitted to the patient, and judged to be satisfactory by both the patient and clinician.