Abstract
A chitosan (CS) powder treated with cinnamic acid and an analogue compound (CN) was prepared as CS-CN. Using it, bile acid adsorption by CS-CN and the release of CN were investigated in vitro. When CS-CN was soaked in a taurocholate solution, it released CN and simultaneously adsorbed the bile acid. For CS-CN prepared with cinnamic acid, the amount of CN released was 0.286 +/- 0.001 mmol/g CS-CN; the amount of taurocholate adsorbed was 0.284 +/- 0.003 mmol/g CS-CN. These two functions were recognized on alginate or pectin gel beads containing CS-CN. The amount of released CN was altered extensively by the species of CN used for gel-bead preparation. Results suggest that CS-CN is a candidate for complementary medicine to prevent lifestyle-related diseases.
MeSH terms
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Adsorption*
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Alginates / chemistry
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Antioxidants / chemistry
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Bile Acids and Salts / chemistry*
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Chitosan / metabolism*
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Chitosan / pharmacokinetics*
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Cinnamates / chemistry*
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Coumaric Acids / chemistry
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Gastric Juice / metabolism
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Glucuronic Acid / chemistry
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Glycocholic Acid / chemistry
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Glycocholic Acid / pharmacokinetics
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Hexuronic Acids / chemistry
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Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism
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Models, Biological
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Pharmaceutical Preparations / chemical synthesis
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Powders / chemistry
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Taurocholic Acid / chemistry
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Taurodeoxycholic Acid / chemistry
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Vanillic Acid / chemistry
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X-Ray Diffraction
Substances
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Alginates
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Antioxidants
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Bile Acids and Salts
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Cinnamates
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Coumaric Acids
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Hexuronic Acids
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Pharmaceutical Preparations
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Powders
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cinnamic acid
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Taurodeoxycholic Acid
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Taurocholic Acid
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Glucuronic Acid
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Chitosan
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Glycocholic Acid
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Vanillic Acid