Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12(beta or alpha)-dihydroartemisinoxymethyl(or 1'-ethyl)]phenoxyl propionic acids and esters

Bioorg Med Chem. 2006 Dec 1;14(23):8043-9. doi: 10.1016/j.bmc.2006.07.038.

Abstract

Another series of novel dihydroartemisinin derivatives were synthesized and assessed for their cytotoxicity of lymphocyte, inhibitory activity on mitogen-induced spleen lymphocyte proliferation in vitro. Some of the compounds exhibited inhibitory effects on ConA-induced T cell and LPS-induced B cell proliferation comparable to or more potent than parent artemisinin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Artemisinins / chemical synthesis*
  • Artemisinins / pharmacology*
  • B-Lymphocytes / drug effects
  • Cell Proliferation / drug effects
  • Concanavalin A / pharmacology
  • Esters
  • Immunosuppressive Agents / chemical synthesis*
  • Immunosuppressive Agents / pharmacology
  • Lipopolysaccharides / pharmacology
  • Lymphocytes / drug effects
  • Propionates / chemical synthesis
  • Propionates / pharmacology
  • Sesquiterpenes / chemical synthesis*
  • Sesquiterpenes / pharmacology*
  • Spleen / cytology

Substances

  • Artemisinins
  • Esters
  • Immunosuppressive Agents
  • Lipopolysaccharides
  • Propionates
  • Sesquiterpenes
  • Concanavalin A
  • artemisinin