Abstract
Another series of novel dihydroartemisinin derivatives were synthesized and assessed for their cytotoxicity of lymphocyte, inhibitory activity on mitogen-induced spleen lymphocyte proliferation in vitro. Some of the compounds exhibited inhibitory effects on ConA-induced T cell and LPS-induced B cell proliferation comparable to or more potent than parent artemisinin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Artemisinins / chemical synthesis*
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Artemisinins / pharmacology*
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B-Lymphocytes / drug effects
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Cell Proliferation / drug effects
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Concanavalin A / pharmacology
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Esters
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Immunosuppressive Agents / chemical synthesis*
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Immunosuppressive Agents / pharmacology
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Lipopolysaccharides / pharmacology
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Lymphocytes / drug effects
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Propionates / chemical synthesis
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Propionates / pharmacology
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology*
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Spleen / cytology
Substances
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Artemisinins
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Esters
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Immunosuppressive Agents
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Lipopolysaccharides
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Propionates
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Sesquiterpenes
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Concanavalin A
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artemisinin