Abstract
A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-d-xylopyranoside (2) and cimigenol 3-O-alpha-l-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC(50) value of 28.6 microm, whereas compounds 2 and 3 were inactive.
Copyright (c) 2006 John Wiley & Sons, Ltd.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzopyrans / pharmacology
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Cimicifuga / chemistry*
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Complement Inactivating Agents / isolation & purification
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Complement Inactivating Agents / pharmacology*
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Complement Pathway, Classical / drug effects*
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Flavonoids
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Lactones / chemistry*
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Lactones / isolation & purification
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Lactones / pharmacology
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Male
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Methanol / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rhizome / chemistry
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Sheep
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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25-O-acetylcimigenol-3-O-beta-D-xylopyranoside
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Benzopyrans
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Complement Inactivating Agents
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Flavonoids
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Glycosides
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Lactones
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Plant Extracts
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Triterpenes
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cimigenol 3-O-alpha-L-arabinopyranoside
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cimilactone A
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tiliroside
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Methanol