Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida

Phytother Res. 2006 Nov;20(11):945-8. doi: 10.1002/ptr.1982.

Abstract

A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-beta-d-xylopyranoside (2) and cimigenol 3-O-alpha-l-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC(50) value of 28.6 microm, whereas compounds 2 and 3 were inactive.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzopyrans / pharmacology
  • Cimicifuga / chemistry*
  • Complement Inactivating Agents / isolation & purification
  • Complement Inactivating Agents / pharmacology*
  • Complement Pathway, Classical / drug effects*
  • Flavonoids
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Lactones / chemistry*
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Male
  • Methanol / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Rhizome / chemistry
  • Sheep
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • 25-O-acetylcimigenol-3-O-beta-D-xylopyranoside
  • Benzopyrans
  • Complement Inactivating Agents
  • Flavonoids
  • Glycosides
  • Lactones
  • Plant Extracts
  • Triterpenes
  • cimigenol 3-O-alpha-L-arabinopyranoside
  • cimilactone A
  • tiliroside
  • Methanol