Association of HLA antigens with wound healing process was investigated in Georgian patients. Based on the peculiarities of the wound healing process dynamics, two groups of patients have been distinguished. The first group included 22 patients with primary intention of the operative wounds, while the second group included 30 patients with complicated course of the wound healing process. Control group was comprised by 492 healthy persons. Our study showed that the distribution of HLA antigens is different in these groups. The genetically determined risk of development of wound complications was significantly higher in individuals with HLA-DR1 having the relative risk 3,56.