Nuclear import of spliceosomal snRNPs

Can J Physiol Pharmacol. 2006 Mar-Apr;84(3-4):367-76. doi: 10.1139/y05-101.

Abstract

Uridine-rich small nuclear ribonucleoproteins (U snRNPs) are the building units of the spliceosome. These RNA and protein complexes assemble in the cytoplasm. After proper assembly and RNA maturation, mature U snRNPs are imported into the cell nucleus, where they take part in the splicing process. In this paper we review the current knowledge of how U snRNPs enter the nucleus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Guanosine / analogs & derivatives*
  • Guanosine / metabolism
  • Microscopy, Electron
  • Nuclear Localization Signals / metabolism
  • Nuclear Pore / metabolism
  • Oocytes / metabolism
  • Ribonucleoproteins, Small Nuclear / metabolism*
  • Xenopus

Substances

  • Nuclear Localization Signals
  • Ribonucleoproteins, Small Nuclear
  • Guanosine
  • N(2),N(2),7-trimethylguanosine