Abstract
Uridine-rich small nuclear ribonucleoproteins (U snRNPs) are the building units of the spliceosome. These RNA and protein complexes assemble in the cytoplasm. After proper assembly and RNA maturation, mature U snRNPs are imported into the cell nucleus, where they take part in the splicing process. In this paper we review the current knowledge of how U snRNPs enter the nucleus.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Active Transport, Cell Nucleus
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Animals
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Guanosine / analogs & derivatives*
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Guanosine / metabolism
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Microscopy, Electron
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Nuclear Localization Signals / metabolism
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Nuclear Pore / metabolism
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Oocytes / metabolism
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Ribonucleoproteins, Small Nuclear / metabolism*
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Xenopus
Substances
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Nuclear Localization Signals
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Ribonucleoproteins, Small Nuclear
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Guanosine
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N(2),N(2),7-trimethylguanosine