Synthesis of 2'-amino-LNA purine nucleosides

Nucleosides Nucleotides Nucleic Acids. 2006;25(8):843-7. doi: 10.1080/15257770600793729.

Abstract

The first reported synthesis of 2'-amino-LNA purine nucleosides via a transnucleosidation is accomplished enabling the preparation of oligonucleotides incorporating 2'-amino-LNA with all four natural bases.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Bridged-Ring Compounds / chemical synthesis*
  • Guanosine / analogs & derivatives*
  • Guanosine / chemical synthesis
  • Purine Nucleosides / chemical synthesis*

Substances

  • Bridged-Ring Compounds
  • Purine Nucleosides
  • Guanosine
  • Adenosine