Abstract
Several approaches are currently being pursued in order to improve the efficacy of influenza vaccines in elderly individuals and others who have impaired immune responses to conventional influenza vaccines. There are two influenza vaccines available for elderly subjects: Fluad (Chiron) and Invivac (Solvay Pharmaceuticals). The present clinical study was a randomized, endpoint-blind, parallel group study in elderly subjects aged 61 years and older to investigate the safety and immunogenicity of these vaccines as compared to a standard influenza vaccine Invivac (Solvay Pharmaceuticals). The three vaccines had similar immunogenicity results, whereas the tolerability profile of Invivac was better as compared to Fluad.
Publication types
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adjuvants, Immunologic / adverse effects
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Adjuvants, Immunologic / pharmacology*
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Aged
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Aged, 80 and over
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Drug Delivery Systems*
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Humans
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Influenza Vaccines / administration & dosage*
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Influenza Vaccines / adverse effects
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Influenza Vaccines / immunology
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Influenza Vaccines / standards
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Safety
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Vaccines, Inactivated / administration & dosage*
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Vaccines, Inactivated / adverse effects
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Vaccines, Inactivated / immunology
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Vaccines, Subunit / adverse effects
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Vaccines, Subunit / immunology
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Vaccines, Virosome / administration & dosage*
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Vaccines, Virosome / adverse effects
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Vaccines, Virosome / immunology
Substances
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Adjuvants, Immunologic
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Influenza Vaccines
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Vaccines, Inactivated
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Vaccines, Subunit
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Vaccines, Virosome