CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population

Mult Scler. 2006 Aug;12(4):511-4. doi: 10.1191/135248506ms1314sr.

Abstract

The allele C in the CD24 gene has been related to multiple sclerosis (MS). In this work we check this single nucleotide polymorphism (SNP) in a population of 135 patients and 285 controls. Our results confirm the association between the V/V genotype at aa 57 of this gene and MS and highlight the importance of taking into account the origin of the subjects to avoid a population bias.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • CD24 Antigen / genetics*
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Spain / epidemiology
  • White People / genetics

Substances

  • CD24 Antigen
  • CD24 protein, human