Long-term retention of dye after indocyanine green-assisted internal limiting membrane peeling

Jpn J Ophthalmol. 2006 Jul-Aug;50(4):349-353. doi: 10.1007/s10384-006-0325-1.

Abstract

Purpose: To evaluate dye retention in the fundus after indocyanine green (ICG)-assisted internal limiting membrane peeling.

Methods: Ten eyes with stage 3 or 4 nondiabetic idiopathic macular hole (MH group) and six eyes with diffuse diabetic macular edema (DM group) were studied. The fundus was examined with 780-nm infrared illumination by a scanning laser ophthalmoscope (SLO) after ICG-assisted internal limiting membrane peeling. The postoperative follow-up period ranged from 6 to 12 months (mean+/-SD, 3.7+/-2.6 months).

Results: Fluorescence from ICG was detected in all studied eyes in both groups up to 6 months after surgery. At 9 months after surgery, ICG fluorescence was visible in all eyes of the DM group, but in only one-third of eyes of the MH group. No fluorescence was detected in fellow eyes that had not been operated on.

Conclusion: The present study using SLO revealed that ICG remains in the fundus for over 6 months after surgery. The results also suggested that a longer time might be required for dye clearance from the diabetic retina than from the nondiabetic retina.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Coloring Agents / pharmacokinetics*
  • Diabetic Retinopathy / complications
  • Diabetic Retinopathy / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Indocyanine Green / pharmacokinetics*
  • Macular Edema / etiology
  • Macular Edema / pathology
  • Macular Edema / surgery*
  • Male
  • Microscopy, Electron, Transmission
  • Middle Aged
  • Ophthalmoscopy / methods
  • Retinal Perforations / pathology
  • Retinal Perforations / surgery*
  • Time Factors
  • Treatment Outcome
  • Vitrectomy / methods*
  • Vitreous Body / metabolism*
  • Vitreous Body / surgery
  • Vitreous Body / ultrastructure

Substances

  • Coloring Agents
  • Indocyanine Green