Treatment monitoring and response prediction with proton MR spectroscopy in AD

F Jessen; F Traeber; K Freymann; W Maier; H H Schild; W Block

doi:10.1212/01.wnl.0000228218.68451.31

Treatment monitoring and response prediction with proton MR spectroscopy in AD

Neurology. 2006 Aug 8;67(3):528-30. doi: 10.1212/01.wnl.0000228218.68451.31.

Authors

F Jessen¹, F Traeber, K Freymann, W Maier, H H Schild, W Block

Affiliation

¹ Department of Psychiatry, University of Bonn, Germany. jessen@uni-bonn.de

PMID: 16894124
DOI: 10.1212/01.wnl.0000228218.68451.31

Abstract

In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease / metabolism*
Aspartic Acid / analogs & derivatives*
Aspartic Acid / metabolism
Creatine / metabolism*
Female
Humans
Magnetic Resonance Spectroscopy*
Male
Monitoring, Ambulatory
Protons

Substances

Protons
Aspartic Acid
N-acetylaspartate
Creatine