Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B

Clin Vaccine Immunol. 2006 Aug;13(8):972-4. doi: 10.1128/CVI.00396-05.

Abstract

Persistent infection with hepatitis B virus (HBV) likely depends on viral inhibition of host defenses. We report that chronic hepatitis B e antigen-positive HBV infection is associated with a significant reduction in peripheral blood monocyte expression of Toll-like receptor 2, a key component of innate immunity, thereby providing a mechanism by which wild-type HBV may establish persistent infection.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Antigens, Viral / immunology
  • Antigens, Viral / pharmacology
  • Down-Regulation
  • Female
  • Hepatitis B virus / immunology*
  • Hepatitis B, Chronic / immunology*
  • Humans
  • Immunity, Innate
  • Leukocytes, Mononuclear / immunology*
  • Lipopolysaccharide Receptors / metabolism
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Monocytes / immunology*
  • Monocytes / metabolism
  • Toll-Like Receptor 2 / metabolism*
  • Tumor Necrosis Factor-alpha / analysis

Substances

  • Antigens, Viral
  • Lipopolysaccharide Receptors
  • Toll-Like Receptor 2
  • Tumor Necrosis Factor-alpha