False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria

Anne F Gasasira; Grant Dorsey; Moses R Kamya; Diane Havlir; Moses Kiggundu; Philip J Rosenthal; Edwin D Charlebois

doi:10.1128/JCM.02207-05

False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria

J Clin Microbiol. 2006 Aug;44(8):3021-4. doi: 10.1128/JCM.02207-05.

Authors

Anne F Gasasira¹, Grant Dorsey, Moses R Kamya, Diane Havlir, Moses Kiggundu, Philip J Rosenthal, Edwin D Charlebois

Affiliation

¹ Department of Medicine, Makerere University Medical School, Kampala, Uganda.

Abstract

Malaria may impact upon human immunodeficiency virus (HIV) test results. We evaluated two HIV enzyme immunoassays (EIAs) by testing 1,965 Ugandans with malaria. We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

AIDS Serodiagnosis*
Age Factors
False Positive Reactions
HIV Infections / diagnosis*
Humans
Immunoenzyme Techniques*
Malaria / complications*
Predictive Value of Tests
Uganda

Abstract

Publication types

MeSH terms

Grants and funding