Surgical site infection is one of the most important health problems representing an increase in morbi-mortality and economical devastation for the patient. There have been a variety of procedures that surgeons have employed to control this situation, from very refined surgical procedures, advanced antimicrobial therapy to local therapy with alginates, hydrocolloid dressings and many others with active topical substances. One of the newest treatments is the VAC (Vacuum-Assisted Closure). This therapy has been proven to be useful in wound infection control and we used it to carry out this study in 38 patients with wound infections. We present the results with this therapy in our institution.