Abstract
Three new arylnaphthalene lignans, namely phyllanthusmins A-C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzodioxoles / chemistry*
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Benzodioxoles / pharmacology*
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Benzofurans / chemistry*
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Benzofurans / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Glycosides / chemistry*
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Glycosides / pharmacology*
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Humans
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Inhibitory Concentration 50
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Lignans / chemistry*
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Molecular Structure
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Naphthalenes / chemistry*
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Phyllanthus / chemistry*
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Plant Preparations / chemistry
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Spectrum Analysis
Substances
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Benzodioxoles
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Benzofurans
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Glycosides
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Lignans
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Naphthalenes
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Plant Preparations
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phyllanthusmin A
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phyllanthusmin B
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phyllanthusmin C