Synthesis, crystal structure, and DNA-binding study on the trinitrate{2,2'-[2,3-naphthylenebis(oxy)]-bis(N,N-diisopropyl(acetamide))} gadolinium(III) complex

Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1150-4. doi: 10.1248/cpb.54.1150.

Abstract

A 2,2'-[2,3-naphthylenebis(oxy)]-bis(N,N-diisopropyl(acetamide)) ligand (L) and its Gd(III) complex have been prepared and characterized. The crystal and molecular structure of the complex was determined by single-crystal X-ray diffraction. The interactions of complex with calf thymus DNA were investigated by UV-vis, fluorescence and viscosity measurements. Experimental results indicated that the complex can bind to DNA by intercalation modes. Its intrinsic binding constant is 1.03 x 10(6) M(-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • DNA / chemistry*
  • DNA / metabolism*
  • Gadolinium / chemistry*
  • Ligands
  • Nitrates / chemistry*
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Spectrometry, Fluorescence

Substances

  • Ligands
  • Nitrates
  • Organometallic Compounds
  • trinitrato(2,2'-(2,3-naphthylenebis(oxy))bis(N,N-diisopropyl(acetamide)))gadolinium(III)
  • DNA
  • Gadolinium