Abstract
A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacokinetics*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacokinetics*
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Chlorine / chemistry*
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Escherichia coli / drug effects
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Fluorine / chemistry*
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Gram-Positive Cocci / drug effects
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Mannich Bases / chemical synthesis
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Mannich Bases / chemistry
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Mitosporic Fungi / drug effects
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Molecular Structure
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Pseudomonas aeruginosa / drug effects
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Schiff Bases / chemical synthesis
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Schiff Bases / chemistry
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Mannich Bases
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Schiff Bases
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Fluorine
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Chlorine