Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers

Jae Yeol Lee; Seong Jun Park; Sung Jun Park; Min Joo Lee; Hyewhon Rhim; Seon Hee Seo; Ki-Sun Kim

doi:10.1016/j.bmcl.2006.07.046

Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers

Bioorg Med Chem Lett. 2006 Oct 1;16(19):5014-7. doi: 10.1016/j.bmcl.2006.07.046. Epub 2006 Jul 28.

Authors

Jae Yeol Lee¹, Seong Jun Park, Sung Jun Park, Min Joo Lee, Hyewhon Rhim, Seon Hee Seo, Ki-Sun Kim

Affiliation

¹ Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Seoul 130-701, Republic of Korea. ljy@khu.ac.kr

PMID: 16876410
DOI: 10.1016/j.bmcl.2006.07.046

Abstract

This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Calcium / metabolism
Calcium Channel Blockers / chemical synthesis
Calcium Channel Blockers / chemistry*
Calcium Channel Blockers / pharmacology
Calcium Channels, T-Type
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects*
Drug Screening Assays, Antitumor
Humans
Neoplasms / drug therapy
Neoplasms / pathology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Calcium Channel Blockers
Calcium Channels, T-Type
Calcium