Abstract
Pharmacokinetics of a novel nootropic agent, alaptide, have been examined in plasma and brain of mice, rats and rabbits following an intravenous dose (1 mg kg-1). First-order equilibration rate constants between plasma and brain (kBO) were calculated by a two-compartment model with a linked compartment (brain). Brain alaptide equilibrates rapidly with the central compartment in mice and rats due to the high kBO/beta ratio. In rabbits the equilibration is much slower (kBO/beta approximately 1). Partition coefficients between brain and plasma calculated from areas under the brain and plasma concentration-time curves, are 0.479, 0.549 and 0.864, in mice, rats and rabbits, respectively.
MeSH terms
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Animals
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Brain / metabolism
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Chinchilla
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Chromatography, Thin Layer
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In Vitro Techniques
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Male
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Mice
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Models, Biological
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Neuropeptides / administration & dosage
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Neuropeptides / blood
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Neuropeptides / pharmacokinetics*
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Neuropeptides / urine
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Peptides, Cyclic / administration & dosage
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Peptides, Cyclic / blood
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Peptides, Cyclic / pharmacokinetics*
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Peptides, Cyclic / urine
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Protein Binding
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Psychotropic Drugs / administration & dosage
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Psychotropic Drugs / blood
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Psychotropic Drugs / pharmacokinetics*
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Psychotropic Drugs / urine
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Rabbits
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Rats
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Rats, Inbred Strains
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Serum Albumin, Bovine
Substances
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Neuropeptides
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Peptides, Cyclic
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Psychotropic Drugs
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Serum Albumin, Bovine
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cyclo(alanine-(1-amino-1-cyclopentane)carbonyl)