Venous ulcers are significant both surgical and dermatological problem. The chronic and recurrent natures of the disease require a search for new methods to improve treatment efficiency. Therefore, the attempts at using some physical methods are needed. The authors review the current literature on characteristics and biological effects of high voltage stimulation (HVS), ultrasound (sonotherapy) and laser biostimulation. Modern hypotheses (skin battery theory, cavitation, acoustic streaming, fotobiostimulation effect) explaining the mechanisms of applied physical factors arising in soft tissue healing process are presented too.