Abstract
Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled receptor (NTS3). Here, we review the transduction mechanisms, cellular trafficking, and potential physiological roles of these two unconventional receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Vesicular Transport
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Animals
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Biological Transport, Active
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Humans
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology
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Receptors, Neurotensin / classification
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Receptors, Neurotensin / genetics
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Receptors, Neurotensin / physiology*
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Signal Transduction
Substances
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Adaptor Proteins, Vesicular Transport
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Receptors, Neurotensin
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Recombinant Proteins
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sortilin