Single amino acid substitutions alter the efficiency of docking in modular polyketide biosynthesis

Chembiochem. 2006 Sep;7(9):1334-42. doi: 10.1002/cbic.200600185.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution / genetics*
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Gas Chromatography-Mass Spectrometry
  • Lactones / metabolism
  • Macrolides / metabolism
  • Models, Molecular
  • Molecular Sequence Data
  • Molecular Structure
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism
  • Mutagenesis, Site-Directed
  • Polyketide Synthases / genetics
  • Polyketide Synthases / metabolism*
  • Protein Engineering / methods*
  • Protein Structure, Tertiary / genetics
  • Saccharopolyspora / genetics
  • Saccharopolyspora / metabolism
  • Sequence Homology, Amino Acid
  • Transformation, Genetic

Substances

  • Lactones
  • Macrolides
  • Multienzyme Complexes
  • Polyketide Synthases