Abstract
We investigated ertapenem-susceptible and -resistant extended-spectrum beta-lactamase-producing Enterobacter cloacae isolates obtained from the same patient. Gene transcription of OmpD and OmpF was diminished in the ertapenem-resistant isolate. An efflux pump inhibitor decreased the MICs of ertapenem in the resistant strain, suggesting a potential role of efflux pumps in ertapenem resistance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Outer Membrane Proteins / metabolism*
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Drug Resistance, Microbial / genetics
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Enterobacter cloacae / drug effects*
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Enterobacter cloacae / genetics
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Enterobacter cloacae / isolation & purification
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Ertapenem
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Gene Expression Regulation, Bacterial
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Genes, Bacterial
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Humans
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Membrane Transport Proteins / metabolism*
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Microbial Sensitivity Tests
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Transcription, Genetic
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beta-Lactams / pharmacology*
Substances
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Membrane Transport Proteins
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beta-Lactams
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Ertapenem