Abstract
Aims and background:
Patients included in clinical trials are "selected", and they usually differ from those commonly treated.
Methods:
From 1999 to 2004, in the Medical Oncology Department of Padua (Italy), 70 metastatic colorectal cancers were treated with FOLFOX4.
Results:
Our results, compared with those of the registration trial (response rate, duration of response and progression-free survival) appeared lower; overall survival was improved.
Conclusions:
The number of therapeutic regimens more than their type influenced the results.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / pathology
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Disease-Free Survival
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Drug Administration Schedule
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Female
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Fluorouracil / administration & dosage
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Humans
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Leucovorin / administration & dosage
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Male
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Middle Aged
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Organoplatinum Compounds / administration & dosage
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Retrospective Studies
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Survival Analysis
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Treatment Outcome
Substances
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Organoplatinum Compounds
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Leucovorin
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Fluorouracil