Efficacy of betaxolol in neuroleptic-induced akathisia

Psychiatry Res. 1991 Nov;39(2):193-8. doi: 10.1016/0165-1781(91)90087-6.

Abstract

Betaxolol, a beta 1-selective antagonist, produced marked improvement in eight patients with neuroleptic-induced akathisia. No further improvement was seen with subsequent propranolol treatment. These findings, along with the results of prior studies of betaxolol and metoprolol, suggest that blockade of central beta 1-receptors may be sufficient for efficacy in akathisia.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Akathisia, Drug-Induced*
  • Antipsychotic Agents / adverse effects*
  • Antipsychotic Agents / therapeutic use
  • Betaxolol / therapeutic use*
  • Drug Administration Schedule
  • Humans
  • Middle Aged
  • Neurologic Examination
  • Propranolol / therapeutic use
  • Psychomotor Agitation / drug therapy*
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / psychology*
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology*

Substances

  • Antipsychotic Agents
  • Propranolol
  • Betaxolol