Feasibility study concerning the use of expert systems for the development of procedures in pharmaceutical analysis

M R Detaevernier; Y Michotte; L Buydens; M P Derde; M Desmet; L Kaufman; G Musch; J Smeyers-Verbeke; A Thielemans; L Dryon; D L Massart

doi:10.1016/0731-7085(86)80051-6

Feasibility study concerning the use of expert systems for the development of procedures in pharmaceutical analysis

J Pharm Biomed Anal. 1986;4(3):297-307. doi: 10.1016/0731-7085(86)80051-6.

Authors

M R Detaevernier¹, Y Michotte, L Buydens, M P Derde, M Desmet, L Kaufman, G Musch, J Smeyers-Verbeke, A Thielemans, L Dryon, D L Massart

Affiliation

¹ Pharmaceutical Institute, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.

PMID: 16867595
DOI: 10.1016/0731-7085(86)80051-6

Abstract

The feasibility of using expert systems for the development of analytical procedures is investigated. A system for the computer generation of procedures to determine active drug substances in commercial formulations is proposed. It is shown that in nearly 85% of the cases investigated the present system immediately yields a correct procedure or conclusion. It is concluded that selecting methods and developing procedures with the use of expert systems is difficult but feasible.