Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression

Fredrik Granberg; Catharina Svensson; Ulf Pettersson; Hongxing Zhao

doi:10.1016/j.virol.2006.06.019

Adenovirus-induced alterations in host cell gene expression prior to the onset of viral gene expression

Virology. 2006 Sep 15;353(1):1-5. doi: 10.1016/j.virol.2006.06.019. Epub 2006 Jul 24.

Authors

Fredrik Granberg¹, Catharina Svensson, Ulf Pettersson, Hongxing Zhao

Affiliation

¹ Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.

PMID: 16860366
DOI: 10.1016/j.virol.2006.06.019

Abstract

In this report, we have studied gene expression profiles in human primary lung fibroblasts (IMR-90) during the very early phase of an adenovirus infection. Eight out of twelve genes with known functions encoded transcription factors linked to two major cellular processes; inhibition of cell growth (ATF3, ATF4, KLF4, KLF6 and ELK3) and immune response (NR4A1 and CEBPB), indicating that the earliest consequences of an adenovirus infection are growth arrest and induction of an immune response. A time course analysis showed that the induction of these immediate-early response genes was transient and suppressed after the onset of the adenovirus early gene expression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenovirus Infections, Human / genetics
Adenovirus Infections, Human / metabolism*
Adenoviruses, Human / genetics
Adenoviruses, Human / physiology*
Cell Line
Fibroblasts / metabolism
Gene Expression
Gene Expression Profiling
Gene Expression Regulation, Viral*
Genes, Immediate-Early
Genes, Viral*
Humans
Kinetics
Kruppel-Like Factor 4
Lung / cytology
Transcription Factors / genetics
Transcription Factors / metabolism

Substances

KLF4 protein, human
Kruppel-Like Factor 4
Transcription Factors