Test a clade in phylogenetic trees

Mol Biol Evol. 2006 Oct;23(10):1976-83. doi: 10.1093/molbev/msl065. Epub 2006 Jul 20.

Abstract

We develop a new method for testing a portion of a tree (called a clade) based on multiple tests of many 4-taxon trees in this paper. This is particularly useful when the phylogenetic tree constructed by other methods have a clade that is difficult to explain from a biological point of view. The statement about the test of the clade can be made through the multiple P values from these individual tests. By controlling the familywise error rate or the false discovery rate (FDR), 4 different tree test methods are evaluated through simulation methods. It shows that the combination of the approximately unbiased (AU) test and the FDR-controlling procedure provides strong power along with reasonable type I error rate and less heavy computation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biometry
  • Chi-Square Distribution
  • Classification
  • Computer Simulation
  • Data Interpretation, Statistical
  • Databases, Genetic
  • Models, Genetic
  • Phylogeny*